AMD EPYC 7281 's Advantages
Lower TDP (170W vs 225W)
AMD EPYC 7453 's Advantages
Released 3 years and 9 months late
Higher specification of memory (3200 vs 2666)
Newer PCIe version (4 vs 3)
Higher base frequency (2.75GHz vs 2.1GHz)
Larger L3 cache size (64MB vs 32MB)
More modern manufacturing process (7nm vs 14nm)