AMD EPYC 7261 's Advantages
Higher base frequency (2.5GHz vs 2.3GHz)
Lower TDP (170W vs 225W)
AMD EPYC 7643 's Advantages
Released 2 years and 9 months late
Higher specification of memory (3200 vs 2666)
Newer PCIe version (4 vs 3)
Larger L3 cache size (256MB vs 32MB)
More modern manufacturing process (7nm vs 14nm)