AMD EPYC 7301 's Advantages
Released 10 years and 4 months late
Higher specification of memory (DDR4-2666 vs DDR2-667)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)
Opteron 8220 's Advantages
Higher base frequency (2.8GHz vs 2.2GHz)
Lower TDP (95W vs 170W)