AMD EPYC 7451 's Advantages
Lower TDP (180W vs 225W)
AMD EPYC 7642 's Advantages
Released 2 years and 2 months late
Higher specification of memory (3200 vs 2666)
Newer PCIe version (4 vs 3)
Higher base frequency (2.4GHz vs 2.3GHz)
Larger L3 cache size (256MB vs 64MB)
More modern manufacturing process (7nm vs 14nm)