AMD EPYC 7451 's Advantages
Higher base frequency (2.3GHz vs 2.25GHz)
Lower TDP (180W vs 360W)
AMD EPYC 9754S 's Advantages
Released 6 years late
Higher specification of memory (4800 vs 2666)
Newer PCIe version (5 vs 3)
Larger L3 cache size (256MB vs 64MB)
More modern manufacturing process (5nm vs 14nm)