AMD EPYC 7451 's Advantages
Released 8 years late
Higher specification of memory (2666 vs 1333)
Newer PCIe version (3 vs 2)
Larger L3 cache size (64MB vs 6MB)
More modern manufacturing process (14nm vs 45nm)
Opteron 1381 's Advantages
Higher base frequency (2.5GHz vs 2.3GHz)
Lower TDP (115W vs 180W)