AMD EPYC 7451 's Advantages
Released 4 years and 6 months late
Higher specification of memory (2666 vs 3)
Newer PCIe version (3 vs 2)
Larger L3 cache size (64MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)
Opteron 3380 's Advantages
Higher base frequency (2.6GHz vs 2.3GHz)
Lower TDP (65W vs 180W)