AMD EPYC 7451 's Advantages
Higher base frequency (2.3GHz vs 2.2GHz)
Lower TDP (180W vs 330W)
Xeon 6780E 's Advantages
Released 7 years late
Higher specification of memory (6400 vs 2666)
Newer PCIe version (5 vs 3)
Larger L3 cache size (108MB vs 64MB)
More modern manufacturing process (5nm vs 14nm)