AMD EPYC 7452 's Advantages
Released 6 years and 9 months late
Higher specification of memory (3200 vs 1866)
Newer PCIe version (4 vs 2)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)
Opteron 6376 's Advantages
Higher base frequency (2.3GHz vs 2.2GHz)
Lower TDP (115W vs 155W)