AMD EPYC 9645 's Advantages
Released 12 years and 5 months late
Higher specification of memory (6000 vs 3)
Newer PCIe version (5 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (3nm vs 32nm)
Opteron 6278 's Advantages
Higher base frequency (2.4GHz vs 2.3GHz)
Lower TDP (115W vs 320W)