Intel Xeon E 2378G 's Advantages
Higher base frequency (2.8GHz vs 1.8GHz)
Lower TDP (80W vs 185W)
Intel Xeon Gold 6421N 's Advantages
Released 1 years and 4 months late
Higher specification of memory (4400 vs 3200)
Newer PCIe version (5 vs 4)
Larger L3 cache size (60MB vs 16MB)
More modern manufacturing process (10nm vs 14nm)