Intel Xeon E3 1280 's Advantages
Higher base frequency (3.5GHz vs 2.3GHz)
Lower TDP (95W vs 225W)
AMD EPYC 7643P 's Advantages
Released 12 years and 5 months late
Higher specification of memory (3200 vs 3)
Newer PCIe version (4 vs 3)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)