Intel Xeon E5 2649 v3 's Advantages
Higher base frequency (2.3GHz vs 2.1GHz)
Lower TDP (105W vs 250W)
Intel Xeon Platinum 9221 's Advantages
Released 4 years and 7 months late
Higher specification of memory (DDR4-2933 vs DDR3)
Larger L3 cache size (71.5MB vs 25MB)
More modern manufacturing process (14nm vs 22nm)