Intel Xeon E5 2680 's Advantages
Higher base frequency (2.7GHz vs 2.6GHz)
Larger L3 cache size (20MB vs 16MB)
Intel Xeon E 2378 's Advantages
Released 9 years and 6 months late
Higher specification of memory (DDR4-3200 vs DDR3)
Newer PCIe version (4 vs 3)
More modern manufacturing process (14nm vs 32nm)
Lower TDP (65W vs 130W)