Intel Xeon E5649 's Advantages
Higher base frequency (2.533GHz vs 2.3GHz)
Lower TDP (80W vs 180W)
AMD EPYC 7451 's Advantages
Released 6 years and 4 months late
Higher specification of memory (2666 vs 3)
Newer PCIe version (3 vs 2)
Larger L3 cache size (64MB vs 12MB)
More modern manufacturing process (14nm vs 32nm)