Intel Xeon Platinum 9221 's Advantages
Released 6 years and 4 months late
Higher specification of memory (DDR4-2933 vs DDR3)
Newer PCIe version (3 vs 2)
Larger L3 cache size (71.5MB vs 8MB)
Opteron 3380 's Advantages
Higher base frequency (2.6GHz vs 2.1GHz)
Lower TDP (65W vs 250W)