Opteron 1381 's Advantages
Higher base frequency (2.5GHz vs 2.25GHz)
Lower TDP (115W vs 360W)
AMD EPYC 9754S 's Advantages
Released 14 years late
Higher specification of memory (4800 vs 1333)
Newer PCIe version (5 vs 2)
Larger L3 cache size (256MB vs 6MB)
More modern manufacturing process (5nm vs 45nm)