Opteron 2212 HE (F2) 's Advantages
Lower TDP (68W vs 170W)
AMD EPYC 7281 's Advantages
Released 10 years and 10 months late
Higher specification of memory (DDR4-2666 vs DDR2)
Newer PCIe version (3 vs 1)
Higher base frequency (2.1GHz vs 2GHz)
More modern manufacturing process (14nm vs 90nm)