Opteron 2214 HE (F3) 's Advantages
Higher base frequency (2.2GHz vs 1.8GHz)
Lower TDP (68W vs 185W)
Intel Xeon Gold 6421N 's Advantages
Released 16 years and 5 months late
Higher specification of memory (DDR5-4400 vs DDR2)
Newer PCIe version (5 vs 1)