Opteron 2218 (F3) 's Advantages
Higher base frequency (2.6GHz vs 2.1GHz)
Lower TDP (95W vs 170W)
AMD EPYC 7281 's Advantages
Released 10 years and 10 months late
Higher specification of memory (2666 vs 2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)