Opteron 2218 (F3) 's Advantages
Higher base frequency (2.6GHz vs 2.4GHz)
Lower TDP (95W vs 115W)
Opteron 6278 's Advantages
Released 5 years and 9 months late
Higher specification of memory (3 vs 2)
Newer PCIe version (2 vs 1)
More modern manufacturing process (32nm vs 90nm)