Opteron 2222 SE 's Advantages
Higher base frequency (3GHz vs 2.2GHz)
Lower TDP (119W vs 170W)
AMD EPYC 7301 's Advantages
Released 10 years and 2 months late
Higher specification of memory (2666 vs 2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)