Opteron 2222 SE 's Advantages
Higher base frequency (3GHz vs 2GHz)
Lower TDP (119W vs 240W)
AMD EPYC 7663 's Advantages
Released 13 years and 11 months late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)