Opteron 2222 's Advantages
Higher base frequency (3GHz vs 2.85GHz)
Lower TDP (95W vs 200W)
AMD EPYC 7443 's Advantages
Released 13 years and 7 months late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)