Opteron 2222 's Advantages
Higher base frequency (3GHz vs 2.3GHz)
Lower TDP (95W vs 180W)
AMD EPYC 7451 's Advantages
Released 9 years and 10 months late
Higher specification of memory (2666 vs 2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)