Opteron 2222 's Advantages
Higher base frequency (3GHz vs 2.2GHz)
Lower TDP (95W vs 330W)
Xeon 6780E 's Advantages
Released 16 years and 10 months late
Higher specification of memory (6400 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (5nm vs 90nm)