Opteron 4376 HE 's Advantages
Lower TDP (65W vs 170W)
AMD EPYC 4564P 's Advantages
Released 11 years and 5 months late
Higher specification of memory (DDR5-5200 vs DDR3)
Higher base frequency (4.5GHz vs 2.6GHz)
Larger L3 cache size (64MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)