Opteron 6276 's Advantages
Higher base frequency (2.3GHz vs 2.2GHz)
Lower TDP (115W vs 155W)
AMD EPYC 7452 's Advantages
Released 7 years and 9 months late
Higher specification of memory (3200 vs 3)
Newer PCIe version (4 vs 2)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)