Opteron 6276 's Advantages
Lower TDP (115W vs 290W)
AMD EPYC 9454 's Advantages
Released 11 years late
Higher specification of memory (4800 vs 3)
Newer PCIe version (5 vs 2)
Higher base frequency (2.75GHz vs 2.3GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)