Opteron 6278 's Advantages
Higher base frequency (2.4GHz vs 2GHz)
Lower TDP (115W vs 150W)
Intel Xeon Gold 5416S 's Advantages
Released 10 years and 8 months late
Higher specification of memory (4400 vs 3)
Newer PCIe version (5 vs 2)
Larger L3 cache size (30MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)