Opteron 6376 's Advantages
Higher base frequency (2.3GHz vs 2.25GHz)
Lower TDP (115W vs 500W)
AMD EPYC 9965 's Advantages
Released 11 years and 11 months late
Higher specification of memory (6000 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (384MB vs 8MB)
More modern manufacturing process (3nm vs 32nm)