Opteron 6378 's Advantages
Higher base frequency (2.4GHz vs 2GHz)
Lower TDP (115W vs 175W)
AMD EPYC 8534PN 's Advantages
Released 10 years and 10 months late
Higher specification of memory (4800 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)