Opteron 6378 's Advantages
Lower TDP (115W vs 400W)
AMD EPYC 9745 's Advantages
Released 11 years and 11 months late
Higher specification of memory (6000 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (3nm vs 32nm)