Opteron 6378 's Advantages
Higher base frequency (2.4GHz vs 2GHz)
Lower TDP (115W vs 205W)
Intel Xeon Gold 5420 's Advantages
Released 10 years and 2 months late
Higher specification of memory (4400 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (52.5MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)