Opteron 8216 HE (F3) 's Advantages
Lower TDP (68W vs 105W)
AMD EPYC 4464P 's Advantages
Released 17 years and 9 months late
Higher specification of memory (5200 vs 667)
Newer PCIe version (5 vs 1)
Higher base frequency (3.7GHz vs 2.4GHz)
More modern manufacturing process (5nm vs 90nm)