Opteron 8220 SE (F2) 's Advantages
Higher base frequency (2.8GHz vs 2.4GHz)
Lower TDP (120W vs 225W)
AMD EPYC 7642 's Advantages
Released 13 years late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)