Opteron 8220 SE (F2) 's Advantages
Lower TDP (120W vs 320W)
AMD EPYC 9375F 's Advantages
Released 18 years and 2 months late
Higher specification of memory (6000 vs 667)
Newer PCIe version (5 vs 1)
Higher base frequency (3.85GHz vs 2.8GHz)
More modern manufacturing process (4nm vs 90nm)