Opteron 8220 SE (F3) 's Advantages
Higher base frequency (2.8GHz vs 2.25GHz)
Lower TDP (120W vs 360W)
AMD EPYC 9754 's Advantages
Released 16 years and 10 months late
Higher specification of memory (4800 vs 667)
Newer PCIe version (5 vs 1)
More modern manufacturing process (5nm vs 90nm)