Opteron 8220 SE (F3) 's Advantages
Higher specification of memory (667 vs 3)
Higher base frequency (2.8GHz vs 2.4GHz)
Opteron 6278 's Advantages
Released 5 years and 9 months late
Newer PCIe version (2 vs 1)
More modern manufacturing process (32nm vs 90nm)
Lower TDP (115W vs 120W)