Opteron 8220 's Advantages
Higher base frequency (2.8GHz vs 2.4GHz)
Lower TDP (95W vs 130W)
AMD EPYC 7303P 's Advantages
Released 16 years and 7 months late
Higher specification of memory (DDR4-3200 vs DDR2-667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)