Opteron 8222 SE 's Advantages
Higher base frequency (3GHz vs 2.85GHz)
Lower TDP (120W vs 200W)
AMD EPYC 7443P 's Advantages
Released 13 years and 11 months late
Higher specification of memory (DDR4-3200 vs DDR2-667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)