Opteron 8222 SE 's Advantages
Higher base frequency (3GHz vs 2.25GHz)
Lower TDP (120W vs 500W)
AMD EPYC 9965 's Advantages
Released 17 years and 6 months late
Higher specification of memory (6000 vs 667)
Newer PCIe version (5 vs 1)
More modern manufacturing process (3nm vs 90nm)