Xeon E 2488 's Advantages
Released 11 years and 9 months late
Higher specification of memory (4800 vs 3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (24MB vs 10MB)
More modern manufacturing process (10nm vs 32nm)
Lower TDP (95W vs 130W)
Intel Xeon E5 2643 's Advantages
Higher base frequency (3.3GHz vs 3.2GHz)