Xeon E 2488 's Advantages
Released 11 years late
Higher specification of memory (4800 vs 3)
Higher base frequency (3.2GHz vs 2.6GHz)
Larger L3 cache size (24MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)
Opteron 4376 HE 's Advantages
Lower TDP (65W vs 95W)