Qualcomm Snapdragon 680 Advantages
Higher Frequency (2400MHz vs 2342MHz)
More modern manufacturing process (6nm vs 14nm)
Released 5 years and 2 months late
Qualcomm Snapdragon 821 Advantages
Better graphics card performance FLOPS (0.3343 TFLOPS vs 0.284 TFLOPS )
Larger memory bandwidth (29.8GB/s vs 17GB/s)