AMD EPYC 7251 's Advantages
Higher base frequency (2.1GHz vs 1.8GHz)
Lower TDP (120W vs 185W)
Intel Xeon Gold 6421N 's Advantages
Released 5 years and 7 months late
Higher specification of memory (DDR5-4400 vs DDR4-2400)
Newer PCIe version (5 vs 3)
Larger L3 cache size (60MB vs 32MB)