AMD EPYC 7281 's Advantages
Lower TDP (170W vs 225W)
AMD EPYC 7543 's Advantages
Released 3 years and 9 months late
Higher specification of memory (DDR4-3200 vs DDR4-2666)
Newer PCIe version (4 vs 3)
Higher base frequency (2.8GHz vs 2.1GHz)
Larger L3 cache size (256MB vs 32MB)
More modern manufacturing process (7nm vs 14nm)