AMD EPYC 7281 's Advantages
Lower TDP (170W vs 270W)
Intel Xeon Gold 6454S 's Advantages
Released 5 years and 7 months late
Higher specification of memory (DDR5-4800 vs DDR4-2666)
Newer PCIe version (5 vs 3)
Higher base frequency (2.2GHz vs 2.1GHz)
Larger L3 cache size (60MB vs 32MB)