AMD EPYC 7451 's Advantages
Lower TDP (180W vs 225W)
AMD EPYC 7453 's Advantages
Released 3 years and 9 months late
Higher specification of memory (3200 vs 2666)
Newer PCIe version (4 vs 3)
Higher base frequency (2.75GHz vs 2.3GHz)
More modern manufacturing process (7nm vs 14nm)