AMD EPYC 7543 's Advantages
Released 14 years and 1 months late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
Higher base frequency (2.8GHz vs 2.6GHz)
More modern manufacturing process (7nm vs 90nm)
Opteron 8218 HE 's Advantages
Lower TDP (68W vs 225W)